Paget's Disease

Paget's disease disrupts the normal cycle of bone renewal and repair, causing bones to become weakened and deformed.

Paget disease is a disorder that involves abnormal bone destruction and regrowth. This results in deformity of the affected bones.

Paget's disease of bone - Comprehensive overview covers symptoms, causes, treatment of this chronic disorder.

NORD gratefully acknowledges Roy D. Altman, MD, Professor of Medicine, Division of Rheumatology and Immunology, University of California, Los Angeles, for assistance in the preparation of this report.

Scientists do not know for sure what causes Paget’s disease. In some cases, the disease runs in families, and so far two genes have been identified that predispose affected people to develop Paget’s disease. In most cases, however, scientists suspect that environmental factors play a role. For example, scientists are studying the possibility that a slow-acting virus may cause Paget’s disease.

Learn about Paget Disease of Bone symptoms, diagnosis and treatment in the Merck Manual. HCP and Vet versions too!

Paget's disease is a disorder that involves abnormal bone destruction and regrowth. This results in deformity of the affected bones.

Paget disease is a localized disorder of bone remodeling that typically begins with excessive bone resorption followed by an increase in bone formation.

A fact sheet about Paget disease of the breast, a rare type of cancer that is sometimes called Paget disease of the nipple or mammary Paget disease.

Wikipedia's information about Paget's Disease of Bone.

Read about Paget's disease causes, symptoms, statistics, prognosis, diagnosis and treatment. Learn about Sir James Paget, who discovered the bone disorder.

Paget's disease of bone - Comprehensive overview covers symptoms, causes, treatment of this chronic disorder.

Information on Paget's disease of the bone for patients and caregivers, such as: what it is, common symptoms, getting diagnosed, and treatment options.

What is Paget's disease? Paget's disease is a problem of abnormal bone growth. It may affect just one bone, but it usually affects more than one.In normal bone, the bone tissue is constantly being broken down, absorbed into the body, and then rebuilt with new cells. In Paget's disease, bone tissue is broken down and absorbed much faster than normal, so the body speeds up the bone rebuilding process. But this new bone is often weak and brittle, and it breaks easily.Paget's disease is most common in people older than 50, and the risk of getting it increases with age. Most people who have it are able to lead normal lives. What causes Paget's disease?The cause of Paget's disease is not clear.

Paget's disease of bone is a chronic disease of the skeleton. It is a common disease in older people, occurring in about 3 percent to 4 percent of the population over age 50. It is slightly more common in men than women.