Klinefelter Syndrome

Roseanna Partridge

@rosksj

Causes, symptoms, diagnostic procedures and criteria, treatments and prognoses for Klinefelter Syndrome, a genetic disorder experienced by males with two X chromosomes.

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Roseanna Partridge

@rosksj

Causes, symptoms, diagnostic procedures and criteria, treatments and prognoses for Klinefelter Syndrome, a genetic disorder experienced by males with two X chromosomes.

Klinefelter Syndrome - MedlinePlus

Klinefelter syndrome is a genetic condition that occurs in males when they have an extra X chromosome.
https://medlineplus.gov/ency/article/000382.htm
Klinefelter Syndrome Treatment and Management - eMedicine

Early identification and anticipatory guidance are extremely helpful, although Klinefelter syndrome is rarely diagnosed in prepubertal males. Treatment should address 3 major facets of the disease: hypogonadism, gynecomastia, and psychosocial problems.
http://emedicine.medscape.com/article/945649-treatment?pa=nXa11ISAPzMTUtWLnqD9kOVQBNlXRgqCh2KLJzIW7PtYa2CibJSXPhksRnQDVgIMcTjXoTc7K9JdzLX0SzNSwMxINcH%2BsxRbWLj4dpGggpU%3D
Klinefelter Syndrome - Mayo Clinic

Klinefelter syndrome occurs as a result of a random error that causes a male to be born with an extra sex chromosome. Of the 46 human chromosomes, the two sex chromosomes determine a person's sex. In females, both sex chromosomes are X (written as XX). Males have an X and a Y sex chromosome (XY).
http://www.mayoclinic.org/diseases-conditions/klinefelter-syndrome/basics/causes/con-20033637
Klinefelter Syndrome, Topic Overview - WebMD

Klinefelter syndrome is a genetic disorder that affects males. Klinefelter syndrome occurs when a boy is born with one or more extra X chromosomes.
http://www.webmd.com/men/tc/klinefelter-syndrome-topic-overview#1
Klinefelter Syndrome - NHS Choices

NHS Choices information on Klinefelter syndrome, with links to other useful resources.
http://www.nhs.uk/Conditions/klinefelters-syndrome/Pages/Introduction.aspx
Klinefelter Syndrome - Mayo Clinic

Klinefelter syndrome - Comprehensive overview covers treatment, diagnosis of this genetic condition affecting males.
http://www.mayoclinic.org/diseases-conditions/klinefelter-syndrome/basics/definition/con-20033637
Learning About Klinefelter Syndrome - NIH

Humans have 46 chromosomes, which contain all of a person's genes and DNA. Two of these chromosomes, the sex chromosomes, determine a person?s gender. Both of the sex chromosomes in females are called X chromosomes. (This is written as XX.) Males have an X and a Y chromosome (written as XY). The two sex chromosomes help a person develop fertility and the sexual characteristics of their gender.
https://www.genome.gov/19519068
Klinefelter Syndrome - Genetics Home Reference

Klinefelter syndrome is a chromosomal condition that affects male physical and cognitive development. Its signs and symptoms vary among affected individuals. Affected individuals typically have small testes that do not produce as much testosterone as usual. Testosterone is the hormone that directs male sexual development before birth and during puberty. Learn more here.
http://ghr.nlm.nih.gov/condition/klinefelter-syndrome
Klinefelter's Syndrome; Extra X Chromosome. Genetic Disorder - Patient

Klinefelter's syndrome is a genetic condition that only affects males. Affected males have an extra X chromosome.
http://patient.info/health/klinefelters-syndrome-leaflet
Klinefelter Syndrome: Background, Pathophysiology, Epidemiology - Medscape

In 1942, Klinefelter et al published a report on 9 men who had enlarged breasts, sparse facial and body hair, small testes, and an inability to produce sperm. In 1959, these men with Klinefelter syndrome were discovered to have an extra X chromosome (genotype XXY) instead of the usual male sex complement (genotype XY).
http://emedicine.medscape.com/article/945649-overview
Klinefelter Syndrome: Here Are the Symptoms

Learn about Klinefelter syndrome (XXY condition), a genetic disease affecting males. Symptoms include low testosterone levels, reduced strength, male breasts, wide hips, and reduced muscle tone.
http://www.medicinenet.com/klinefelter_syndrome/article.htm
Klinefelter Syndrome - TeensHealth

This genetic condition only affects guys and is also called "XXY." It can affect a guy's ability to learn and his sexual development, but doctors can treat it. Find out more.
http://kidshealth.org/en/teens/klinefelter.html
Klinefelter's Syndrome Association

We offer support and information to all affected by, or having an interest in, Klinefelter's Syndrome.
http://www.ksa-uk.net
Klinefelter Syndrome - NORD (National Organization for Rare Disorders)

NORD gratefully acknowledges Jeannie Visootsak, MD, FAAP, Associate Professor, Developmental-Behavioral Pediatrics, Department of Human Genetics and Pediatrics, Emory University School of Medicine, for assistance in the preparation of this report.
http://rarediseases.org/rare-diseases/klinefelter-syndrome/
Klinefelter Syndrome - Wikipedia, the Free Encyclopedia

Wikipedia's information about Kilinefelter syndrome.
https://en.wikipedia.org/wiki/Klinefelter_syndrome

Comments

Klinefelter syndrome
Other names	XXY syndrome, Klinefelter's syndrome, Klinefelter-Reifenstein-Albright syndrome

47,XXY karyotype
Pronunciation	/ˈklaɪnfɛltər/
Specialty	Medical genetics
Symptoms	Varied; include above average height, weaker muscles, poor coordination, less body hair, breast growth, small testicle size, less interest in sex, infertility^[1]
Complications	Infertility, intellectual disability,^[2] autoimmune disorders, breast cancer, venous thromboembolic disease, osteoporosis
Usual onset	At fertilisation^[3]
Duration	Lifelong
Causes	Nondisjunction during gametogenesis or in a zygote^[4]
Risk factors	Older age of mother^[5]
Diagnostic method	Genetic testing (karyotype)^[6]
Prevention	None
Treatment	Physical therapy, speech and language therapy, Testosterone Supplementation, counseling^[7]
Prognosis	Nearly normal life expectancy^[8]
Frequency	1 in 500–1000^[5]^[9]
Named after	Harry Klinefelter

Source : Wikipedia under CC-BY-SA license

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Media

Klinefelter Syndrome - MedlinePlus

Klinefelter syndrome is a genetic condition that occurs in males when they have an extra X chromosome.
https://medlineplus.gov/ency/article/000382.htm
Klinefelter Syndrome Treatment and Management - eMedicine

Early identification and anticipatory guidance are extremely helpful, although Klinefelter syndrome is rarely diagnosed in prepubertal males. Treatment should address 3 major facets of the disease: hypogonadism, gynecomastia, and psychosocial problems.
http://emedicine.medscape.com/article/945649-treatment?pa=nXa11ISAPzMTUtWLnqD9kOVQBNlXRgqCh2KLJzIW7PtYa2CibJSXPhksRnQDVgIMcTjXoTc7K9JdzLX0SzNSwMxINcH%2BsxRbWLj4dpGggpU%3D
Klinefelter Syndrome - Mayo Clinic

Klinefelter syndrome occurs as a result of a random error that causes a male to be born with an extra sex chromosome. Of the 46 human chromosomes, the two sex chromosomes determine a person's sex. In females, both sex chromosomes are X (written as XX). Males have an X and a Y sex chromosome (XY).
http://www.mayoclinic.org/diseases-conditions/klinefelter-syndrome/basics/causes/con-20033637
Klinefelter Syndrome, Topic Overview - WebMD

Klinefelter syndrome is a genetic disorder that affects males. Klinefelter syndrome occurs when a boy is born with one or more extra X chromosomes.
http://www.webmd.com/men/tc/klinefelter-syndrome-topic-overview#1
Klinefelter Syndrome - NHS Choices

NHS Choices information on Klinefelter syndrome, with links to other useful resources.
http://www.nhs.uk/Conditions/klinefelters-syndrome/Pages/Introduction.aspx
Klinefelter Syndrome - Mayo Clinic

Klinefelter syndrome - Comprehensive overview covers treatment, diagnosis of this genetic condition affecting males.
http://www.mayoclinic.org/diseases-conditions/klinefelter-syndrome/basics/definition/con-20033637
Learning About Klinefelter Syndrome - NIH

Humans have 46 chromosomes, which contain all of a person's genes and DNA. Two of these chromosomes, the sex chromosomes, determine a person?s gender. Both of the sex chromosomes in females are called X chromosomes. (This is written as XX.) Males have an X and a Y chromosome (written as XY). The two sex chromosomes help a person develop fertility and the sexual characteristics of their gender.
https://www.genome.gov/19519068
Klinefelter Syndrome - Genetics Home Reference

Klinefelter syndrome is a chromosomal condition that affects male physical and cognitive development. Its signs and symptoms vary among affected individuals. Affected individuals typically have small testes that do not produce as much testosterone as usual. Testosterone is the hormone that directs male sexual development before birth and during puberty. Learn more here.
http://ghr.nlm.nih.gov/condition/klinefelter-syndrome
Klinefelter's Syndrome; Extra X Chromosome. Genetic Disorder - Patient

Klinefelter's syndrome is a genetic condition that only affects males. Affected males have an extra X chromosome.
http://patient.info/health/klinefelters-syndrome-leaflet
Klinefelter Syndrome: Background, Pathophysiology, Epidemiology - Medscape

In 1942, Klinefelter et al published a report on 9 men who had enlarged breasts, sparse facial and body hair, small testes, and an inability to produce sperm. In 1959, these men with Klinefelter syndrome were discovered to have an extra X chromosome (genotype XXY) instead of the usual male sex complement (genotype XY).
http://emedicine.medscape.com/article/945649-overview
Klinefelter Syndrome: Here Are the Symptoms

Learn about Klinefelter syndrome (XXY condition), a genetic disease affecting males. Symptoms include low testosterone levels, reduced strength, male breasts, wide hips, and reduced muscle tone.
http://www.medicinenet.com/klinefelter_syndrome/article.htm
Klinefelter Syndrome - TeensHealth

This genetic condition only affects guys and is also called "XXY." It can affect a guy's ability to learn and his sexual development, but doctors can treat it. Find out more.
http://kidshealth.org/en/teens/klinefelter.html
Klinefelter's Syndrome Association

We offer support and information to all affected by, or having an interest in, Klinefelter's Syndrome.
http://www.ksa-uk.net
Klinefelter Syndrome - NORD (National Organization for Rare Disorders)

NORD gratefully acknowledges Jeannie Visootsak, MD, FAAP, Associate Professor, Developmental-Behavioral Pediatrics, Department of Human Genetics and Pediatrics, Emory University School of Medicine, for assistance in the preparation of this report.
http://rarediseases.org/rare-diseases/klinefelter-syndrome/
Klinefelter Syndrome - Wikipedia, the Free Encyclopedia

Wikipedia's information about Kilinefelter syndrome.
https://en.wikipedia.org/wiki/Klinefelter_syndrome

Klinefelter syndrome
Other names	XXY syndrome, Klinefelter's syndrome, Klinefelter-Reifenstein-Albright syndrome

47,XXY karyotype
Pronunciation	/ˈklaɪnfɛltər/
Specialty	Medical genetics
Symptoms	Varied; include above average height, weaker muscles, poor coordination, less body hair, breast growth, small testicle size, less interest in sex, infertility^[1]
Complications	Infertility, intellectual disability,^[2] autoimmune disorders, breast cancer, venous thromboembolic disease, osteoporosis
Usual onset	At fertilisation^[3]
Duration	Lifelong
Causes	Nondisjunction during gametogenesis or in a zygote^[4]
Risk factors	Older age of mother^[5]
Diagnostic method	Genetic testing (karyotype)^[6]
Prevention	None
Treatment	Physical therapy, speech and language therapy, Testosterone Supplementation, counseling^[7]
Prognosis	Nearly normal life expectancy^[8]
Frequency	1 in 500–1000^[5]^[9]
Named after	Harry Klinefelter

Source : Wikipedia under CC-BY-SA license

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Klinefelter Syndrome

Causes, symptoms, diagnostic procedures and criteria, treatments and prognoses for Klinefelter Syndrome, a genetic disorder experienced by males with two X chromosomes.

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