Huntington's disease

Huntington's disease (HD) is a hereditary and progressive brain disorder. You can't "catch" it from another person.

Huntington's disease is a genetic, progressive, neurodegenerative disorder characterized by the gradual development of involuntary muscle movements affecting the hands, feet, face, and trunk and progressive deterioration of cognitive processes and memory (dementia).

Debunking myths about Huntington's Disease

Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.

Huntington's disease can take a long time to diagnose. It is a hereditary illness with numerous symptoms that leave a person unable to walk or talk and needing full-time care. We explain genetic testing, drug treatments, and the state of research to find a cure, plus the stages of the disease and therapies available.

Although records of symptoms have been traced as far back as the Middle Ages, it was not until the late 1800s that physician George Huntington first documented the hereditary nature of the disease that bears his name.

Huntington’s disease is a hereditary condition in which your brain’s nerve cells gradually break down. It can cause physical and psychological symptoms.

Huntington's disease causes a progressive breakdown of nerve cells in the brain. Find out about symptoms, diagnosis and treatment.